Recent Studies with MSM, Glucosamine and Chondroitin
Clinical
Study 1. We would like to share with you important clinical
research that proves the benefits of MSM in combination with
glucosamine. In this recently published, randomized,
double-blind trial, published in the journal Clinical Drug
Investigations, it was found that MSM, glucosamine sulfate,
and their combination produced pain-relief and anti-inflammatory
effects in osteoarthritis of the knee.
Participants
received either 1,500 mg per day of MSM, 1,500 mg per day of
glucosamine sulfate, both, or placebo in the 12-week trial.
Compared to placebo, the nutrients, individually and in
combination, produced statistically significant decreases in the
Lequesne Index, a standardized measurement of the signs and
symptoms of osteoarthritis. The combination of MSM and glucosamine
was more effective than either treatment alone.
The
study provides clinical evidence of synergy between MSM and
glucosamine in combating the symptoms of osteoarthritis. The
publication of these study results validates the conclusions of
Cardinal Nutrition's own recently completed randomized,
double-blind study of OptiMSM for osteoarthritis of the knee.
Since this clinical trial has not yet been published, we are
unable to disclose specific results. However, the findings were
positive, statistically significant, and wholly consistent with
the findings of the MSM/glucosamine study discussed above.
Clinical
Study 2. Chondroitin Sulfate May Slow Knee Osteoarthritis -
Taking chondroitin sulfate supplements over short periods
significantly relieved pain and improved mobility in patients with
knee osteoarthritis, according to researchers. The study,
looking at the effect of chondroitin taken over two three-month
periods during one year, supported the long-term results of the
supplement for osteoarthritis, said an international team writing
in the April issue of Osteoarthritis and Cartilage (vol.12:
269-276).
Osteoarthritis
is a major cause of disability and there is neither an effective
treatment to stop the disease worsening, nor a cure. The only
available treatment is pain relief and replacing the worn out
joints. Knee osteoarthritis affects 14.1 per cent of men and
22.8 per cent of women over the age of 45 but increases in life
expectancy and ageing populations are expected to make
osteoarthritis the fourth leading cause of disability by 2020,
according to the World Health Organization.
In
the new study, the group taking chondroitin sulfate (800 mg daily)
saw symptoms measured by Lequesne’s algo - functional index
(pain and knee function) decrease by 36 per cent after one year
compared to 23 per cent in the placebo group. Secondary measures
of efficacy, such as walking time and paracetamol, also showed
similar results. And X-rays at the end of the study revealed that
while the placebo group patients had significantly decreased
femoro-tibial joint space width, there was no change in the
chondroitin group.
The
researchers conclude that the intermittent administration of
chondroitin sulfate supplements twice a year supports the
prolonged effect seen with other symptom-modifying agents for
osteoarthritis. They add that the inhibitory effect on progression
of joint space narrowing could suggest further evidence of its
ability to improve the condition.
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Mailing Address: P.O. Box 936, Falmouth, MA 02541
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manufacturer of OptiMSMtm
DISCLAIMER
The information contained in this site has been compiled from numerous
studies, research papers and journals for the purpose of offering
consumers and professionals information about our health and nutrition
products. None of the information herein should be construed as a claim
for cure, treatment or prevention of any disease. You should not use the
information contained herein for diagnosing or treating a health problem
or disease, or prescribing any medication. All matters regarding physical
health should be referred to your own health care provider or other
medical professional. The statements in this web site regarding dietary
supplements have not been evaluated by the Food and Drug Administration.
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MSM /Glucosamine /
Chondroitin
