Recent Studies with MSM, Glucosamine and Chondroitin
Study 1. We would like to share with you important clinical
research that proves the benefits of MSM in combination with
glucosamine. In this recently published, randomized,
double-blind trial, published in the journal Clinical Drug
Investigations, it was found that MSM, glucosamine sulfate, and
their combination produced pain-relief and anti-inflammatory effects
in osteoarthritis of the knee.
received either 1,500 mg per day of MSM, 1,500 mg per day of
glucosamine sulfate, both, or placebo in the 12-week trial. Compared
to placebo, the nutrients, individually and in combination, produced
statistically significant decreases in the Lequesne Index, a
standardized measurement of the signs and symptoms of
osteoarthritis. The combination of MSM and glucosamine was more
effective than either treatment alone.
study provides clinical evidence of synergy between MSM and
glucosamine in combating the symptoms of osteoarthritis. The
publication of these study results validates the conclusions of
Cardinal Nutrition's own recently completed randomized, double-blind
study of OptiMSM for osteoarthritis of the knee. Since this clinical
trial has not yet been published, we are unable to disclose specific
results. However, the findings were positive, statistically
significant, and wholly consistent with the findings of the MSM/glucosamine
study discussed above.
Study 2. Chondroitin Sulfate May Slow Knee Osteoarthritis -
Taking chondroitin sulfate supplements over short periods
significantly relieved pain and improved mobility in patients with
knee osteoarthritis, according to researchers. The study,
looking at the effect of chondroitin taken over two three-month
periods during one year, supported the long-term results of the
supplement for osteoarthritis, said an international team writing in
the April issue of Osteoarthritis and Cartilage (vol.12:
is a major cause of disability and there is neither an effective
treatment to stop the disease worsening, nor a cure. The only
available treatment is pain relief and replacing the worn out
joints. Knee osteoarthritis affects 14.1 per cent of men and
22.8 per cent of women over the age of 45 but increases in life
expectancy and ageing populations are expected to make
osteoarthritis the fourth leading cause of disability by 2020,
according to the World Health Organization.
the new study, the group taking chondroitin sulfate (800 mg daily)
saw symptoms measured by Lequesne’s algo - functional index (pain
and knee function) decrease by 36 per cent after one year compared
to 23 per cent in the placebo group. Secondary measures of efficacy,
such as walking time and paracetamol, also showed similar results.
And X-rays at the end of the study revealed that while the placebo
group patients had significantly decreased femoro-tibial joint space
width, there was no change in the chondroitin group.
researchers conclude that the intermittent administration of
chondroitin sulfate supplements twice a year supports the prolonged
effect seen with other symptom-modifying agents for osteoarthritis.
They add that the inhibitory effect on progression of joint space
narrowing could suggest further evidence of its ability to improve